Jane Alcantara (Judy Ann Santos) is the legacy of her mother Rose (Gina Alajar). And in her life she has never loved anyone but her mother and two friends Sam and Nathan. But then her mother falls ill because of her two friends. And when her two friends flee, she vows to seek revenge.

As time passes, Jane struggles to heal her mother and become the nurturing nurse that her mother hoped her to be. And Jane’s journey into the medical world leads her to meet David (Derek Ramsay) – the arrogant heir to the hospital, who becomes her worst enemy but secretly pines for. And Raon (Joem Bascon), the street urchin whom she constantly saves and heals.

And between the two Jane would discover passion with a man whom she truly loves, but then she later discovers, was the cause of her mother’s suffering.