Hiram is a story of friendship challenged to prove that in the midst of a chaotic and doubting world, the power of real love and loyalty will still prevail.
Diana (Kris Aquino) is a downhearted and self-sacrificing woman who is ready to give up her own happiness for the sake of friendship. She is in search of unconditional love that can save her from life’s miseries. Driven by ambition and hate, Sofia (Dina Bonnevie), on the other hand, is enslaved by her past, a dark shadow hinders her to find true happiness in the arms of the man she loves. As their pasts continue to haunt them, they share a future tainted with conflict and rivalry struggling for the love of one man, Edward (John Estrada).
This rivalry continues to the next generation. Margaret (Heart Evangelista) and Stephanie (Anne Curtis), bestfriends bound by loyalty and trust. Their friendship will be put to test as one man, Harry (Geoff Eigenmann) comes between them.
A journey through time, these women will find themselves entangled in a web of deceit, power and betrayal. Their only salvation is their friendship and love for one another.